ESKETAMINE

The First Nasal Spray Medication for Treatment-Resistant Depression

Ketamine is a medication that has been used as a surgical anesthesia around the world for more than 50 years with children, adults, and animals. About 20 years ago, ketamine’s ability to relieve depression, anxiety, and some pain disorders in less than 24 hours after administration was stumbled upon by researchers. Follow-up studies replicating the rapid results have changed researchers’ understanding of depression, revitalizing an area of medical research that had been stagnant for almost three decades.

Esketamine, or Spravato™, is derived from ketamine and makes powerful antidepressant relief available to be delivered intra-nasally, similar to a common nasal decongestant. Ohio Psychiatric Services offers esketamine therapy, and this novel therapy for treatment-resistant depression can be combined with other treatment modalities, such as antidepressants, Transcranial Magnetic Stimulation (TMS), or other therapies.
Nasal Spray Medication for Treatment-Resistant Depression

What is Esketamine Therapy?

Approved in 2019, Esketamine, or Spravato™, is the first nasal spray medication that is a treatment for depression. Spravato™ is a controlled substance and can only be administered at an approved medical facility supervised by a medical provider. Combined with an antidepressant, Spravato™ is FDA-approved to treat depression and has been clinically shown to improve symptoms of depression over just 4 weeks

What is Esketamine Treatment Like?

At our office, the patient will administer the Spravato™ treatment spray under the supervision of one of our healthcare providers. Afterwards, there is a two-hour observation window to monitor for side effects.


Unlike antidepressants, which need to be taken every day, Spravato™ is only administered a couple of times each week: Two treatments per week for the first month, then one treatment per week for the second month, and one treatment every two weeks for subsequent months.


Esketamine therapy patients generally report some sedation and disassociation effects during or shortly after the administration of the drug. Other side effects may include nausea, dizziness, vertigo, or headache.

Is Esketamine Therapy Safe

Is Esketamine Therapy Safe?

Spravato™ has been FDA-approved since 2019 and evaluated in both short- and long-term trials for safety and efficacy. Because Spravato™ is administered in our office, patients will be monitored closely for any adverse side effects.

Before starting esketamine therapy, we will discuss all potential side effects and interactions, and make sure Spravato™ is right for you.

How Soon Will I Feel Better?

Typically, patients respond and can feel better in as little as a week, but it may take longer. Treatment is individualized and is based on your response to the medication. You will continue to work with your current psychiatric provider during the course of your  treatment. You will also be provided weekly wellness checks and progress evaluations by our knowledgeable and well trained providers.

Esketamine Therapy

Our Providers and Esketamine Team